The pharmacological property of a drug, dependent on its physico-chemical structure, is one of the main criteria for inclusion in the pharmacopoeia, particularly western pharmacopoeia. 

This is also the criterion for its use in Mesotherapy, which is inactive if the liquid drug used is not active; for example, distilled water is inactive in Mesotherapy.

Recall that Mesotherapy is a mode of drug administration in the form of micro-depots, of a liquid drug, active imperatively on the condition being treated, randomly created, in the dermis or superficial hypodermis facing the altered area where are located the APs_ Acupuncture Points, of local action, described for millennia as active on this condition.

In Mesopuncture, fluid stimulus of the AP, keeps its pharmacological properties but its physicochemical structure is the fluid stimulus of the AP acting either by its volume or chemical irritation...

Some liquid drugs are of rapid elimination or degradation requiring a daily injection, others are of slow release of 3 weeks for some anti-inflammatories or painkillers others have a slower degradation, 6-12 months if not more.

The duration of fluid stimulus by the liquid drug on the AP is function, of its elimination rate, its bioavailability.

In Mesopuncture, the liquid drug is injected with/without needle in the APs of local action, facing the altered zone, chosen to be active on the medical condition or aesthetics; Mesopuncture completes or potentiates the stimulus by the metal acupuncture needle: Acupuncture and Mesopuncture are often performed with the same device as our BMN.

This effect of fluid stimulus is regained with all the liquid drugs be they with/without pharmacological effect that is to say, neutral, such as distilled water, saline: Mesotherapy being inactive in the latter case.

The deposit or injection of a liquid drug with pharmacological effect divided into micro-deposits, in the thickness of the skin, face an altered body area has a known metabolic pathway:

There is an immediate and direct passage of liquid drug from the subcutaneous to the altered area of the body.

Then the liquid drug passes into the bloodstream to reach the liver where it will be modified to be used by the tissues. It passes again into the blood to reach a second time the weathered zone.

During the treatment with local deposit of liquid drug in the skin, the weathered zone receives twice the liquid drug.

It is difficult to find in the pharmacopoeia, liquid drugs of long or very long duration of action that is to say, long or very long-term elimination of the liquid drug and long or very long stimulus  of the AP, acting in synergy, when injected into an AP with the acupuncture effect obtained by this fluid stimulus.

It is, thus, difficult to have liquid drugs with duration of antalgic or anti-inflammatory action greater than 3 weeks. Injected / deposited in the PA, the stimulation obtained, will last three weeks, too.

Generally speaking, the pharmacological action and Acupuncture effect (resulting from the stimulation) contribute to treat the same condition: Thus, in osteoarthritis of the knee, a liquid drug chosen for its anti-inflammatory action is injected / deposited in the knee APs, active on the pathology of the knee.

There is a synergistic action between on one hand, the two properties of liquid drug, therapeutic pharmacological property and AP stimulus and secondly, the therapeutic benefit, in acupuncture, resulting from this stimulation.

Recall that, as any deposit of liquid drug into the thickness of the skin in front of the weathered zone, the liquid drug is first distributed to this altered zone and then after passage in the blood and liver it is again distributed to the altered zone.

Concerning the liquid drug: It is difficult, if not impossible to dispose of liquid drug with delayed therapeutic effect, long duration of stimulus action, for the various pathologies encountered.

Nowadays, the liquid drugs with notable delay effect are those used in cosmetic and particularly HA and its derivatives which duration of action exceeds the year.

In Mesopuncture, hyaluronic acid is injected into an AP; it stimulates the AP at a time depending on its rate of elimination which is usually of several months.

The HA, having no harmful impact, it is possible to privilege, in Mesopuncture, depending both on the rate of elimination of the liquid drug, its action of long duration stimulation of the AP at the expense of its pharmacological action, to be used in pathologies where are missing the liquid drugs, electively active during more or less time.

It is necessary to well analyze the liquid drug used for its long duration effect and well evaluate its pharmacological action and consequences and precautions for use.

For example, treatment of osteo arthritis of the knee

It is performed by injecting into the selected APs,  few drops of derivatives of hyaluronic acid, of very long duration of action and very long duration of AP stimulus,  without known pharmacological action on osteoarthritis of the knee.

We recall the implants of titanium or steel used in auriculotherapy and the catgut burial technique   used in Acupuncture, of very long stimulating action but without proven therapeutic action.